Statin as a Risk Factor for Cataract in Cases of Antioxidant Gene Polymorphism in Pakistani Population

Introduction: Cataract is main cause of reversible blindness and visual impairment. Risk factors include anti-hyperlipidemic drugs such as statin. However, the mechanism statins a risk factor for cataracts not clear. The antioxidant effect statin reported in some studies while other showed negative results. This study was conducted to understand association cataract users with gene abnormalities.
 Objective: To investigate formation Pakistani population.
 Methods: multi-centric case-control Karachi, Pakistan between September 2019 2020. A single nucleotide polymorphism (SNP) at rs2070424 locus superoxide dismutase (SOD1) gene, rs1050450 glutathione peroxidase (GPX) rs7943316 catalase (CAT), were examined polymerase chain reaction (PCR) using high resolution melting curve (HRM) technique 250 patients.
 Results: ratio seen found that it 1.5 times increased SOD1 mutations, benefit 1.2 reduced GPX mutation 1.1 CAT mutations.
 Conclusion: Statin those patients who have mutated genes. be genes compared non-mutated ones. proved associated development population.